Publications

Selected recent publications from the group:

Lakbub JC, Shipman JT, Desaire H.  Recent mass spectrometry-based techniques and considerations for disulfide bond characterization in proteins.  Anal. Bioanal. Chem., 410(10), 2467-2484 (2018). 

Go EP, Moon HJ, Mure M, Desaire H.  Recombinant human Lysyl Oxidase-Like 2 secreted from human embryonic kidney cells displays complex and acidic glycans at all three N-linked glycosylation sites.  J. Proteome Resch., 17(5), 1826-1832 (2018). 

Hua D, Patabandige MW, Go EP, Desaire, H. The Aristotle Classifier: Using the Whole Glycomic Profile To Indicate a Disease State. Anal. Chem., 91(17), 11070-11077 (2019).  

Shipman JT, Nguyen H, Desaire H.  So you discovered a potential glycan-based biomarker; now what? We developed a high-throughput method for quantitative clinical glycan biomarker validation. ACS Omega 5(12), 6270-6276(2020).  

Hua D, Liu X, Go EP, Wang Y, Hummon AB, Desaire H. How to apply supervised machine learning tools to MS imaging files: Case study with cancer spheroids undergoing treatment with the monoclonal antibody Cetuximab. J. Am. Soc. Mass Spectrom. 31(7), 1350-1357 (2020). 

 Patabandige MW, Go EP, Desaire H. Clinically viable assay for monitoring Uromodulin glycosylation. J. Am. Soc. Mass Spectrom. 32(2), 436-443 (2021). 

Khan MJ, Desaire H, Lopez OL, Kambosh MI, Robinson RAS. Why inclusion matters for Alzheimer's disease biomarker discovery in plasma. J Alzheimers Dis. 79(3), 1327-1344 (2021).

Patabandige MW, Pfeifer LD, Nguyen HT, Desaire H. Quantitative clinical glycomics strategies: A guide for selecting the best analysis approach. Mass Spec. Rev. (2021). DOI: 10.1002/mas.21688 

Go EP, Zhang S, Ding H, Kappes JC, Sodroski JG, Desaire H.  The opportunity cost of automated glycopeptide analysis: case study profiling the SARS-CoV-2 S glycoprotein.  Anal. Bioanal. Chem. 413 (29), 7215-7227 (2021). 

Desaire H, Stepler KE, Robinson RAS. Exposing the brain proteomic signatures of Alzheimer’s disease in diverse racial groups: Leveraging multiple datasets and machine learning. J. Proteome Resch. 21(4), 1095–1104 (2022). 

Meier AA, Go EP, Moon HJ, Desaire H, Mure M.  Mass spectrometry-based disulfide mapping of human lysyl oxidase-like 2.  Int. J. Mol. Sci.23(11), 5879 (2022). 

Pfeifer LD, Patabandige MW, Desaire H.  Leveraging R (LevR) for Fast Processing of Mass Spectrometry Data and Machine Learning: Applications Analyzing Fingerprints and Glycopeptides.  Front. Anal. Sci. (2022). DOI: 10.3389/frans.,2022.961592 

Desaire H.  How (Not) to Generate a Highly Predictive Biomarker Panel Using Machine Learning.  J. Proteome Resch.  21 (9), 2071-2074.  (2022). 

Desaire H, Go EP, Hua D.  Advances, obstacles, and opportunities for machine learning in proteomics.  Cell Reports Phys. Sci. 101069 (2022).   

For more, visit: Dr. Heather Desaire - Google Scholar